Striker Marcelo Moreno scored twice to lead Cruzeiro to a 3-1 win over San Lorenzo on Thursday, putting the Brazilian club through to the next stage of the Copa Libertadores while endangering the Argentines' chances of progressing.
Cruzeiro needed just a draw to advance, and the win made the Belo Horizonte club the third club to reach the last 16 of the 2008 Libertadores, along with fellow Brazilians Fluminense and Ecuador's Liga de Quito.
In other results Thursday, Colombia's Atletico Nacional was held to a 1-1 draw at home by Chile's Audax Italiano, while Uruguay's Nacional beat Peru's Coronel Bolognesi 1-0.
The two-goal losing margin meant San Lorenzo slipped to third place in Group 1 behind Venezuela's Caracas. San Lorenzo must now win its final group game at home against Caracas on April 17 if it to qualify for the last 16 as group runners-up.
Young Bolivian international striker Moreno scored the opening goal in the 11th minute after a well-placed pass from midfielder Ramires.
He made it 2-0 in the 71st minute when he headed home a corner by midfielder Wagner, who 11 minutes later scored his team's third goal.
San Lorenzo striker Silvera scored a consolation goal in the 87th minute.
In Medellin, Atletico Nacional was held to a 1-1 home draw by Audax Italiano in a result that maintained a fine balance in Group 7.
Atletico took the lead in the 59th minute through Paraguayan striker Carlos Villagra, before the Chilean club equalized in the 77th through international midfielder Fabian Orellana.
With all teams in Group 7 having played four games, Brazil's Sao Paulo is top with eight points, three ahead of Atletico, while Audax and Paraguay's Sportivo Luqueno have four points each.
In Montevideo, Nacional moved to the top of Group 4 with the 1-0 win over Coronel Bolognesi, which was eliminated from final 16 contention.
Defender Deivis Barone scored in the 32nd minute in a sluggish match marked by few chances by either side.
The victory gave Nacional nine points from five games. Peru's Cienciano and Brazil's Flamengo both have seven points from four games, while Coronel is out, with just two points from five games.