Barnsley midfielder Brian Howard scored a dramatic late winner to give his side a shock 2-1 win over Liverpool in the fifth round of the FA Cup at Anfield.
Liverpool striker Dirk Kuyt had put his side ahead after he smashed home Ryan Babel's cross in the 32nd minute before Steve Foster equalised with a header for the Coca-Cola Championship side in the 57th minute.
The home side dominated the remainder of the game and Tykes goalkeeper Luke Steele, who was signed on emergency loan from West Brom earlier in the week, produced a string of second-half saves.
The match seemed to be heading for a replay before Howard struck a spectacular winner from 25 yards in the third minute of added time out to put his side into the quarter-final draw.
Chelsea midfielder Frank Lampard scored twice to help give his side a 3-1 win over League One Huddersfield at Stamford Bridge.
Lampard opened the scoring with his 100th Blues goal in the 18th minute after he latched on to a Scott Sinclair cross before he calmly placed the ball into the bottom-left corner of the net.
Huddersfield, though, equalised on the stroke of half-time through midfielder Michael Collins.
James Berrett's pass picked out Collins who drilled the ball home.
Lampard restored the home side's advantage in the 60th minute with a close-range finish after Terriers goalkeeper Matt Glennon had parried his initial shot.
Salomon Kalou was sent clear by Lampard 10 minutes later and added a third after he rounded Glennon to calmly slot the ball home.
Roman Bednar scored twice to help book West Brom's place in the quarter-finals they thrashed 10-man Coventry 5-0 win at the Ricoh Arena.
Chris Brunt had given the Baggies a 12th-minute lead and the home side lost Michael Doyle after he was sent off for a foul on Zoltan Gera.
Bednar scored in the 59th minute after a mistake by Sky Blues goalkeeper Andy Marshall before he converted a penalty 10 minutes later.
Substitute Ishmael Miller added another in the 76th minute and Gera added a fifth two minutes later.
Cardiff midfielder Peter Whittingham scored one goal and created another for Jimmy Floyd Hasselbaink to help give his side a 2-0 win over Wolves at Ninian Park.
Bristol Rovers also caused an upset after they claimed a 1-0 win over Southampton at the Memorial Stadium in the day's early kick-off.
Paul Trollope's Coca-Cola League One team were the better side throughout the match against their Championship counterparts and Rickie Lambert eventually scored the decisive goal in the 84th minute to take his side into the quarter-finals.
The Rovers striker drilled a low free-kick from 22 yards which took a deflection off Saints midfielder Jermaine Wright and sailed past goalkeeper Kelvin Davis.
In the day's late kick-off Manchester United midfielder Darren Fletcher scored twice to help his side complete a 4-0 rout of 10-man Arsenal at Old Trafford.
Wayne Rooney put Sir Alex Ferguson's side in front in the 16th minute and Fletcher also headed home four minutes later to double the advantage.
Luis Nani (38) latched on to Michael Carrick's pass and drilled the ball past Arsenal goalkeeper Jens Lehmann to make it 3-0 before the break.
Arsene Wenger's side were reduced to 10 men four minutes after the interval when Emmanuel Eboue was shown a straight red card for a foul on Patrice Evra.
Fletcher then rounded off the scoring in the 74th minute with a close-range header after good work by Nani down the left flank.