Key Queensland midfielder Matt McKay is rated only a "50-50" chance of playing in Saturday night's home A-League clash against Perth after rolling his ankle at training.
But Brazilian striker Reinaldo is expected to overcome a knee complaint for the Suncorp Stadium showdown as Queensland vies to extend their unbeaten three-game run.
McKay tried to play down his injury when he went down at training on Monday.
However, the Roar are now sweating on the 24-year-old's fitness after he was assessed by medical staff.
"Matt McKay has seen the doctor and he has a moderate sprain of his lateral ankle ligaments," Roar physio Tony Ganter said.
"We'll have to see how he goes in the next couple of days before we can make a decision on him."
Ganter was more hopeful of Reinaldo running out against the win-less Glory.
He injured his knee when he landed awkwardly from a challenge in last round's 1-1 draw at Newcastle.
"It's swollen and a little damaged, but it's not torn (cartilage) which is why he's recovering fast," said Ganter.
"You always hope for the best case scenario and with Reinaldo that's what we have."
Ganter said the final test for Reinaldo would be completing a skills session on Thursday.
The only other fitness concern, rising star Michael Zullo, has overcome a toe complaint and is set to play.
Zullo conceded a penalty last round that ensured Newcastle levelled the scores and held on for a draw against Queensland.
But McKay all but took the blame for the Zullo gaffe.
"I think Josh (McCloughan) and myself can take a bit of the heat off Zullo for conceding the penalty and getting a bit swamped on the wing," McKay said.
"We let him get a bit isolated there and probably should have helped him out a bit more and gotten closer in to assist in front of goal.
"But he's a strong lad and he'll bounce back this weekend, especially with another big game at home."
In other Roar news, Korean import Hyuk-Su Seo, 34, will become the first player in Queensland Roar's short history to reach 50 A-League games for the club.
Queensland is just two points outside the top four with a 3-3-3 (win-draw-loss) record while Perth (0-5-4) is dead last.