Sol Campbell is the latest England player to be ruled out of the pivotal Euro 2008 qualifiers against Israel and Russia.
In a fresh injury blow for England coach Steve McClaren, Portsmouth defender Campbell missed Sunday's 3-1 defeat by Arsenal with a hamstring injury.
Pompey boss Harry Redknapp insists the former Gunners centre-back will be out for a fortnight, adding to McClaren's lengthy list of absentees.
Redknapp said: 'Sol's not fit to play for England.
'We need to get him back and fit to play for Portsmouth in the next two weeks. That's the key.
'We spoke to the doctors and they know he's not fit. I think he will report and then come back to us.'
David Beckham, Frank Lampard, Wayne Rooney, Gary Neville, Ledley King, Wayne Bridge and Jonathan Woodgate have all been ruled out of the England double header.
And with Steven Gerrard and Owen Hargreaves rated doubtful, McClaren could ill afford to loose an experienced campaigner like Campbell.
Redknapp continued: 'We've got to treat Sol and try and get him fit for Liverpool. He is a very important player for us.
'He had a groin problem and now he's gone to his hamstring. He definitely won't be fit to play for England. It is a shame, for sure.'
England, who sit fourth in Group E, host Israel on Saturday and Russia the following Wednesday at Wembley.