Plymouth manager Ian Holloway has called on the club's fans to make Home Park a fortress after being drawn to face Premiership strugglers Watford in the quarter-finals of the FA Cup.
The lowest-ranked team in the competition have the advantage of playing in front of their own fans and Holloway wants the team's supporters to make it count.
He told Sky Sports News: 'To get a home draw for the people of this town is great.
'It's all about a home tie for our fans to get excited about. They made this place a fortress for us on Saturday [in the fifth-round win over Derby] and they need to do it again.
'Aidy [Boothroyd, Watford manager] will be looking at this thinking they can beat us. They never stop working their socks off and there's all sorts of desire and belief.
'But they've got a long journey and let's see if we can make it uncomfortable for them.'
Watford forward Tommy Smith was happy with the draw and believes victory would help his side's bid for Premiership survival.
He said: 'Most clubs want to avoid the bigger clubs so we're fairly pleased with the trip to Plymouth.
'We didn't play brilliantly in the last round and Ipswich gave us a tough time. I think the [cup run] has helped though. It gives you a bit of momentum that you can carry from the cup into the league.'
Reading owner John Madejski will not start thinking about the possibility of a trip to Middlesbrough or West Brom until the result of his side's fifth-round replay against Manchester United is decided.
The Royals drew 1-1 with the Premiership leaders at the weekend and Madejski is focusing on the return fixture.
'We've just got the small business of dispensing with Manchester United before getting excited about Middlesbrough or West Brom but whatever is in front of us we will take on,' he said.
'I'm delighted they [United] are coming back to Reading. That is what the FA Cup is all about.
'It's a second bite of the cherry and it's great. We're all exceedingly excited and looking forward to the game.
'We would be up for it with either of those teams [in the quarter-final] but first we've got the Herculean task of dealing with Manchester United.'
Elsewhere in the draw, Blackburn or Arsenal will host fellow Premiership outfit Manchester City.
Rovers chairman John Williams has called on his players to keep putting in the hard work when the Gunners visit Ewood Park the end of the month and help give manager Mark Hughes a fifth victory in the competition.
Hughes won the cup four times as a player and Williams is keen to help him add another medal to his collection.
'Obviously we've got a difficult replay but we've earned it and it is nice to be at home,' he said.
'Mark's not got a bad record [in the competition] so let's hope we can give him a win as a manager.'
Williams also praised goalkeeper Brad Friedel, whose heroics ensured that Rovers took away a goalless draw from the Emirates Stadium.
'All that work on the training ground pays off, hour after hour,' Williams said.
'Practice makes perfect and it's well done to Brad.'
The draw was completed with reigning Premiership champions Chelsea drawn at home to London rivals Tottenham.
Ties will be played over the weekend of March 10 and 11.