Manchester City booked their place in the FA Cup quarter-finals by storming back at Deepdale.
David Nugent put the Championship side in the driving seat with his 17th goal of the season.
City recovered with Michael Ball, Georgios Samaras and Stephen Ireland finding the target to clinch a emphatic victory.
In the later match on Sunday, Spurs humiliated Fulham at Craven Cottage, hitting four goals past Chris Coleman's side.
The west Londoners had no reply to the Tottenham avalanche, with Spurs striking duo Robbie Keane and Dimitar Berbatov (on as a second half substitute) helping themselves to a brace apiece.
Yesterday's matches saw Reading snatch a surprise replay against Manchester United at Old Trafford.
Michael Carrick put United ahead on the stroke of half-time, firing home Cristiano Ronaldo's lay-off from 25 yards.
But a second-string Royals side refused to lie down and were level shortly after the hour mark when an unmarked Brynjar Gunnarsson rose highest to head John Oster's corner powerfully home via the crossbar.
A pulsating final 20 minutes could have seen either side snatch victory, with Ronaldo and substitute Henrik Larsson both foiled by fantastic saves from Royals keeper Adam Federici.
Kevin Phillips served a timely reminder of his Premiership quality as West Brom twice came from behind to take Middlesbrough to an FA Cup fifth-round replay.
The former Sunderland striker returned to the north-east to snatch a 2-2 draw for the Coca-Cola Championship high-fliers via a deflection off Andrew Taylor.
It was a terrific fightback for the visitors, who conceded a sucker-punch penalty on the stroke of half-time, only moments after making it 1-1.
The result was soured by Curtis Davies' late sending off for an untidy challenge on Mark Viduka.
Boro dominated the early exchanges, with Emanuel Pogatetz having a header cleared off the line before Julio Arca headed in Stewart Downing's brilliant right-wing cross.
The Baggies looked set to go in level when Diomansy Kamara slotted the ball under Mark Schwarzer from a tight angle but Davies then fouled Ayegbeni Yakubu, who then made amends for his two spot-kick misses in the fourth-round replay against Bristol City.
Ten-man Ipswich looked set to join West Brom in the hat for the quarter-final draw before suffering late heartbreak at Watford.
With a replay beckoning, Damien Francis met Tommy Smith's low cross to send the Barclays Premiership's bottom side through.
The visitors' chances of an upset were dealt a blow when George O'Callaghan was sent off on the stroke of half-time.
Making his full debut, the midfielder was given his marching orders after referee Steve Bennett deemed that he had aimed a kick at Hornets defender Danny Shittu.
Ipswich could have earlier been in front when former Fulham midfielder Sylvain Legwinski hit the bar from 25 yards.
The 10 men continued to attack and thought they had taken the lead when Dan Harding's shot hit the underside of the bar and Danny Haynes headed home the rebound only to be denied by the offside flag.
Plymouth reached the quarter-finals for the first time in 23 years thanks to a 2-0 win over Championship leaders Derby.
Kevin Gallen scored a controversial penalty and on-loan Chelsea starlet Scot Sinclair headed in a late second to send Ian Holloway's side through.
Former QPR striker Gallen also missed another penalty, while the Rams had defender Darren Moore sent off.
Gallen earned the first penalty when Dean Leacock was adjudged to have brought him down, despite there appearing to be little contact.
Derby goalkeeper Stephen Bywater got both hands to the spot-kick, turning the ball onto the post, but he was unable to prevent it creeping in.
The second penalty was more clear-cut, Moore penalised for climbing all over Krisztian Timar. Gallen stepped up again but this time Bywater kept his attempt out.
The second half saw Moore dealt a second yellow card for a tackle from behind on Gallen before Sinclair nodded in David Norris' cross to wrap up the win.
Chelsea survived an early scare before turning on the style to crush Norwich 4-0 at Stamford Bridge.
The Premiership champion were indebted to a wicked deflection to go ahead when Shaun Wright-Phillips' long-range shot deflected off a Canaries defender.
Didier Drogba scored his 26th - and easiest - goal of the season to make it 2-0 after a corner had deflected through to him.
Strikes from substitutes Michael Essien and Andriy Shevchenko put a misleading gloss on the scoreline, with Norwich earlier hitting the post through Dickson Etuhu and the bar via Lee Croft.
In the early kick-off, Brad Friedel made a stunning double save from Thierry Henry and Justin Hoyte in the final minutes of the clash at Arsenal to give battling Blackburn a replay at Ewood Park.
The Gunners were also denied a late penalty at the Emirates Stadium after Stephen Warnock's trip on Jeremie Aliadiere 13 minutes from time.
Friedel then threw himself at shots from Henry and Hoyte late on to hand his determined team a second chance as the game finished goalless.