PSV Eindhoven crashed to their second consecutive defeat at champions Ajax to allow FC Twente to take over at the top of the Eredivisie.
Dick Advocaat's PSV saw an eight-game winning run ended by surprise packets Vitesse Arnhem last weekend and a trip to Ajax produced a further blow to their ambitions as they slumped 3-1.
Jeremain Lens had sent PSV into the break level as he fired a 36th-minute equaliser after Siem De Jong opened the scoring seven minutes earlier.
The score remained locked until Danny Hoesen broke through 18 minutes from the end and Viktor Fischer sealed Ajax's win - their fourth on the spin - in the shadows of full-time.
PSV's slip allowed Twente to jump a point clear at the top with a 2-0 win over 10-man ADO Den Haag. Tjaronn Chery saw red on 49 minutes and Twente's goals followed thereafter with Dusan Tadic (55) and Dmitri Bulykin (83) on target.
Fifth-placed Feyenoord remained on the coat-tails of the top clubs after they were also 2-0 winners over RKC Waalwijk. Graziano Pelle (45, 57) grabbed both goals to leave the Rotterdammers four points off the top.
Willem II snatched a second league win 3-1 over Heerenveen although it was not enough to lift them off the foot of the table.
They needed late goals from Hans Mulder (79) and Aurelien Joachim (90) after Alfred Finnbogason (70) had cancelled out Virgil Misidjan's 18th-minute opener. A forgettable night for Heerenveen also saw Jeffrey Gouweleeuw dismissed on 84 minutes.