Markel Susaeta has been handed his first call-up to the Spain squad for the Nov. 14 friendly in Panama.
The Athletic Bilbao midfielder is a surprise inclusion in Vicente del Bosque's side, but has been given his chance following a series of impressive performances at club level.
Barcelona defender Martin Montoya has been called up for the second time. He was an unused member of the Spain squad which faced Chile in a friendly last September.
There is no place for Liverpool goalkeeper Jose Reina either.
The Spain squad for the friendly against Panama on Nov. 14 follows: Valdes (Barcelona), Casillas (Real Madrid); Montoya (Barcelona), Ramos, Albiol (both Real Madrid), Alba (Barcelona), Juanfran (Atletico Madrid), Martinez (Bayern Munich); Iniesta, Fabregas, Busquets (all Barcelona), Cazorla (Arsenal), Benat (Real Betis); Villa (Barcelona), Susaeta (Athletic Bilbao), Pedro (Barcelona), Navas (Sevilla), Soldado (Valencia), Mata (Chelsea).