Colombian giants Millonarios overturned a 3-1 first-leg deficit on Tuesday night to advance to the Copa Sudamericana quarter-finals with a 4-3 aggregate victory over Palmeiras.
Millonarios faced a giant task heading into the second leg in Bogota but got off to the best possible start when Juan Esteban Ortiz opened the scoring just before half-time.
A penalty from Wason Renteria just after the hour and a 77th-minute volley from Lewis Ochoa completed the impressive turnaround for the Blues, who finished the match playing against 10 men after Betinho was sent off for the visitors.
Millonarios now move onto face Gremio or Ecuadorian outfit Barcelona, with the Brazilian side currently up 1-0 with the second leg to be played later this week.
Elsewhere Cerro Porteno progressed to the last eight with the Paraguayan team securing another 2-1 win over Colon to oust the Argentinian side 4-2 overall.
Emmanuel Gigliotti silenced the Asuncion crowd when he headed home Jorge Achucarro's cross to put the visitors ahead after only 60 seconds.
But 10 minutes later Roberto Nanni equalised after neat play between Fidencio Oviedo and Jonathan Fabbro, and then Julio Dos Santos put the result beyond doubt in the 70th minute.
The closing stages were marred by violence in the stands, with the match suspended for around 20 minutes due to trouble between the two sets of fans.
Uruguayan referee Dario Ubriaco decided to complete the match, though, and there was more drama as he showed the red card to Colon duo Diego Pozo and Maximiliano Caire 13 minutes from time.
"It's a real pity that a beautiful spectacle like football suffers this kind of violence,'' Cerro Porteno defender Mariano Uglessich said. "Therefore, the happiness over this qualification isn't complete.''
Cerro Porteno will next face the winners of the tie between Argentinian side Tigre and Deportivo Quito, who will do battle in the second leg in Victoria City on Thursday night with the Ecuadorian team 2-0 up after the first meeting.
Information from the Press Association was used in this report