Boca Juniors won 3-0 at Estudiantes to replace their hosts at the top of the Clausura table.
Boca were 2-0 up inside 24 minutes thanks to goals from Santiago Silva and Pablo Ledesma, before Pablo Mouche rounded off the scoring in the 68th minute.
To make matter worse for Estudiantes, results elsewhere meant they slipped from first to fifth in the table.
Newell's Old Boys beat Racing Club 2-0 to go second, with second-half goals from Maximiliano Urruti and Pablo Perez.
Velez Sarsfield's 2-0 win at San Lorenzo sent them third.
Alejandro Cabral opened the scoring in the eighth minute, but they had to wait until six minutes from the end to get their second through half-time substitute Ivan Bella.
And Arsenal Sarandi also overtook Estudiantes, going fourth with a 2-0 win at All Boys despite playing nearly half the match with 10 men.
Gustavo Leschuk opened the scoring in the 24th minute and Arsenal had a moment of fortune when Mauro Matos missed a penalty just before the break.
Victor Cuesta then saw red two minutes into the second half, but substitute Diego Torres added a second in the 64th minute.
Roberval snatched a point for San Martin San Juan in a 2-2 draw against Colon Santa Fe.
San Martin took the lead in the 36th minute though Marcelo Carrusca, but Javier Chevanton levelled three minutes later and they appeared to have thrown away all three points when Leandro Gonzalez netted in the 87th minute, only for Roberval to intervene a minute later.