FC Twente sent out a message to their Eredevisie title rivals by humiliating PSV with a 6-2 victory at the Philips Stadion.
Willem Janssen struck twice for Steve McClaren's side who completed their remarkable success despite the dismissal of Douglas on 51 minutes.
Twente started the day behind their hosts but were out of sight by half-time as Ola John (eight), Janssen (19), Peter Wisgerhof (35) and Luuk de Jong (40) all netted.
Lorenzo Ebecilio grabbed a hat-trick as Ajax maintained their recent improved form with a straightforward 4-1 defeat of Roda JC .
The Amsterdammers have reignited their title challenge in recent weeks and their fourth successive Eredivisie victory came via a second-half fightback in which Ebecilio was key.
The 20-year-old cancelled out Sanharib Malki's opener and added two more late on after Vurnon Anita had put Ajax in front after 78 minutes.
Feyenoord stayed among the Eredivisie's leading pack with a narrow 1-0 win over FC Groningen thanks to Jordy Clasie's goal just before half-time. It was a key result for Ronald Koeman's side after last weekend's defeat by PSV Eindhoven.
FC Utrecht and NEC Nijmegen played out an uninspiring goalless draw at the Stadion Galgenwaard as neither side were able to pull clear of the bottom three.
NEC remain one point and one place better off than Utrecht in 12th and only two better off than 16th-placed VVV-Venlo, and the result was a bit of a comedown for Nijmegen after their 4-0 win over FC Groningen last weekend ended a run of three defeats.
Vitesse Arnhem deepened De Graafschap's relegation worries with a routine 2-0 win at the Gelredome.
The visitors, who remain second from bottom and in the play-off places, were undone by a goal in each half from Wilfred Bony and Mike Havenaar.