Everton midfielder Steven Pienaar will be out for up to a month after suffering a hamstring injury in training.
The midfielder, 31, missed Saturday’s 1-0 Premier League win over Chelsea after suffering the problem a day earlier.
Manager Roberto Martinez reshuffled his 4-2-3-1 set-up as a result, bringing in Steven Naismith on the right side of midfield and moving Kevin Mirallas to the left to take Pienaar’s place.
Martinez is hopeful that Pienaar will be able to make a comeback in time for the trip to Manchester City on October 5.
Failing that, an international break means that the former South Africa captain would have to wait until the home game against Hull on October 19 for his return.
Forward Arouna Kone also missed the win over Chelsea because of a knee problem, although he is expected to make a quick return.
Martinez told the Liverpool Daily Post: “I think Steven Pienaar is going to be a little bit longer – it's a grade one soft tissue problem. But Arouna Kone shouldn't be too long.”