Pierre-Emerick Aubameyang celebrated a debut to remember for Borussia Dortmund as his hat-trick fired last season's Bundesliga runners-up to a 4-0 win at Augsburg.
• Schaaf: Excitement to start
The new signing from St Etienne scored three as Jurgen Klopp's men responded in style to Bayern Munich's 3-1 win over Borussia Monchengladbach on Friday to keep pace with the defending champions.
Augsburg provided a stern test but ultimately the difference in quality between the two sides shone through, thanks to the Gabon international and a late Robert Lewandowski penalty.
Hertha Berlin stormed to the top of the embryonic Bundesliga table in their first game following promotion with Sami Allagui and Adrian Ramos both grabbing braces in a crushing 6-1 win over Eintracht Frankfurt.
German-American John Anthony Brooks and Ronny also scored for Jos Luhukay's side, who made an ideal start to life back in the top flight. Alexander Meier scored a consolation for the Eagles from the penalty spot, but the pre-season fears of their coach Armin Veh were confirmed in the capital as Hertha became the first promoted side to score six on the opening day of the season.
Bayer Leverkusen's new three-pronged attack inspired them to a fine 3-1 win over Freiburg. Last season's Bundesliga top-scorer Stefan Kiessling put them in front before Mike Hanke opened his account for Freiburg just before the break.
But Heung Min Son and Sidney Sam both struck early in the second half to kill off Freiburg, who saw Jonathan Schmid have a penalty saved.
Hannover took the spoils in the Lower Saxony derby with Leon Andreasen and Szabolcs Huszti on target in a 2-0 win over Wolfsburg.
Andreasen put Mirko Slomka's men in front in the 17th minute, but they had to wait until six minutes from time before being able to celebrate as Huszti sealed the win against the nine-man Wolves.
Maxilimilian Arnold and Timm Klose both received their marching orders for Dieter Hecking's side, who will need to show more discipline if they are to challenge for a place in Europe next season.
Hoffenheim threw away a two-goal lead in a fashion reminiscent of last season as they were held to a 2-2 draw at home to Nurnberg.
David Abraham and Anthony Modeste put Markus Gisdol's men two up while they also had a third goal ruled out. Two goals in three minutes from Mike Frantz and Daniel Ginczek then deprived them of victory and earned Nurnberg a point.