Werder Bremen, Borussia Monchengladbach, Nurnberg and Eintracht Braunschweig became the first Bundesliga sides to be beaten in the first round of the DFB-Pokal on Sunday.
Werder Bremen, playing their first official game under new coach Robin Dutt, were beaten 3-1 in extra time by third-division side Saarbrucken.
After a poor string of results in pre-season, following on from their worst Bundesliga season in 14 years, the alarm bells will already be starting to ring in northern Germany with Sebastian Prodl's goal not enough to prevent them from losing in the first round for the third successive year, and for the third time to third-division opposition.
Bundesliga newcomers Eintracht Braunschweig went down 2-1 to 2. Bundesliga side Arminia Bielefeld while Borussia Monchengladbach were beaten in a penalty shoot-out by Darmstadt.
After a goalless 120 minutes, Luuk de Jong and Branimir Hrgota missed from the spot to give Lucien Favre's side a losing start to the season.
Hannover had no such concerns against Victoria Hamburg with Artur Sobiech and Szabolcs Huszti scoring in a 2-0 win while Greuther Furth saw off Pfeddersheim by the same scoreline.
Information from the Press Association was used in this report.