Paraguayan side Olimpia put one hand on the Copa Libertadores trophy as they beat Brazil's Atletico Mineiro 2-0 in the first leg of the final.
Goals in each half from Alejandro Silva and Wilson Pittoni gave Ever Hugo Almeida's Olimpia a healthy lead ahead of the return match in Belo Horizonte next Wednesday, when they will look to seal their fourth Libertadores crown.
Olimpia were the better side at the Estadio Defensores del Chaco, with their tough midfield and powerful attackers to the fore, while the Brazilian side, typified by former AC Milan and Barcelona playmaker Ronaldinho, struggled.
Uruguayan midfielder Silva put Olimpia ahead in the 22nd minute following a long run that ended with a left-footed shot from outside the box.
That goal gave Olimpia's players more confidence and Juan Manuel Salgueiro could have extended the lead in the 37th minute, but his was just wide of the post.
Four minutes after the interval, Diego Tardelli shot and Ronaldinho failed to deflect that ball into the back of the net to equalise. With the match looking set to finish 1-0, Pittoni gave the home fans cause to celebrate in injury time by netting a free-kick that gave Olimpia a more comfortable lead.
A couple of minutes earlier, Mineiro defender Richarlyson had been shown red and he will miss the return match, as will his team-mate Marcos Rocha who picked up another yellow card.
Pittoni told Fox Sports: "The 2-0 lead is very important but Atletico Mineiro will be hosts next week and we must keep our feet on the ground. They are great players and fortunately we managed to play good football tonight."
Salgueiro added: "This is the lead we had expected on paper, but there are 90 minutes to go and Atletico Mineiro are very powerful as hosts. We did a good job. Mineiro is the best team in the competition and winning was crucial and the goal difference is good considering we know how to defend as visitors."
Information from the Press Association was used in this report.