A hat-trick by Bernard helped Brazilian side Atletico Mineiro to a convincing 5-2 win over Arsenal in Argentina, taking them to the top of Copa Libertadores' Group Three.
Cuca's Atletico Mineiro came back from an early Julio Furch goal to claim a great win in the Southern suburbs of Buenos Aires with a superb performance.
Furch put Arsenal ahead in the second minute of the game with a right-foot strike, but Bernard levelled after Ronaldinho's first assist of the game.
Leandro Donizete assisted Diego Tardelli, who scored Atletico's second goal in the 29th minute and Jo headed home a Donizete cross from the left to make it 3-1 at the 35th.
And though Nicolas Aguirre reduced the deficit with a 41st-minute free-kick to the right-top corner, Bernard consolidated the win by scoring in the 53rd, after another assist by Ronaldinho, and 58th minutes.
World Cup winner Ronaldinho, who missed a penalty in the second period, said: "I am very happy because I played very well for the team. I try to help in building opportunities to score and I took part of many of them."
Arsenal defender Lisandro Lopez, whose side have lost both their Group Three games, told Fox Sports: "This is a very tough group. We are hopeful of progressing, but we know we should not lose points at home."
Argentinian champions Velez Sarsfield joined Penarol on top of Group Four as they defeated the Uruguayan side 1-0 in their trip to Montevideo.
With only three minutes to go, Colombian midfielder Jonathan Copete crossed the ball and Lucas Pratto finished it with his right foot as Velez celebrated their second win in three group matches.
Velez midfielder Federico Insua told Fox Sports: "We planned the game very well. Penarol played good football too and pressured in the first half.
"We defended well and with our second-half form we managed to celebrate a deserved win."
In Colombia, visitors Real Garcilaso of Peru reached the summit of Group Six with a surprise 1-0 win at Tolima.
In injury time, Yoshiro Salazar headed a free-kick and gave Real their second win in three games to remain unbeaten on seven points in their Libertadores debut.
Another team in their first appearance are Mexican league champions Tijuana, who saw off San Jose of Bolivia 4-0 at home.
It was Tijuana's second win in two Group Five matches, with Edgar Castillo opening the scoring in the fourth minute, after a nice combination with Alfredo Moreno.
Paraguayan defender Pablo Aguilar widened the gap two minutes after the interval, while Joe-Benny Corona finished a cross by Fidel Martinez two minutes later.
Finally, Colombian forward Fidel Martinez made it 4-0 with a header at the 74th minute.
Information from the Press Association was used in this report.