PSV moved to the top of the Eredivisie table after a thumping 5-1 triumph over Heerenveen.
Daniel de Ridder gave the visitors a shock fifth-minute lead before Luciano Narsingh levelled things up midway through the first half.
Dick Advocaat's outfit ran riot in the second period as Dries Mertens and Giorgino Wijnaldum found the target before a late brace by Tim Matavz sealed the win.
FC Twente dropped to second after they were held to a goalless draw by third placed Vitesse Arnhem at the GelreDome.
Ajax had no such problems as they hit four at PEC Zwolle.
Centre-half Toby Alderweireld put the visitors ahead in the 12th minute before Viktor Fischer doubled their advantage just after the half hour mark.
Fischer was on hand three minutes after the restart to put Frank de Boer's charges three goals to the good before Siem de Jong, fresh from a brace in their 2-2 midweek Champions League draw at Manchester City made the game safe 14 minutes from time.
Zwolle struck late through Denni Avdic and Jesper Drost, but remain one place off the bottom.
Feyenoord are up to fifth after they were 5-2 victors over struggling Roda JC.
Graziano Pelle gave Ronald Koeman's side the perfect start as he netted after just a minute.
Sanharib Malki equalised 11 minutes later, but Pelle then Lex Immers after 35 minutes put the home side in control.
Bart Biemans gave his side hope five minutes before the interval, but the second half belonged to Feyenoord who eased to the three points thanks to Jordy Clasie and Daryl Janmaat.
Information from the Press Association was used in this report