Brasileiro: Top 5 Goals - Week 34
Flamengo have cancelled Adriano's contract but refused to rule out a future return for the former Brazil striker.
Adriano, 30, only signed a pay-as-you-play deal with the Rio de Janeiro side in August but, after missing three training sessions, a release clause in his contract was activated.
Before Flamengo could discuss his departure, Adriano issued a statement declaring a desire to take a break from professional football at least until the new year.
Off-field problems have dogged the former Inter Milan star's career, and it appears, for the time being at least, that they have got the better of him.
However, Flamengo president Zinho said the Engenhao were keeping the door open in terms of another comeback if the player feels up to it.
He told the club's official website: "Adriano will play no further part for Flamengo, those are his own words. His contract will be rescinded.
"I wanted to speak with him personally on Friday about why he came to this decision, but he was very upset by problems he's having outside of football.
"His first three absences [from training] gave Flamengo the right to terminate the contract, but we took a humane approach to help him recover, ignoring the rules.
"All his doctors, trainers and the players want the best for him, but he has to want it first. It makes me sad because I think he is throwing away a great opportunity. If he recovers, maybe he could be a professional footballer again, and I will keep talking to him as he recovers. As director of football here, he has my support."
Flamengo club president Patricia Amorim echoed Zinho's sentiment, saying the "doors of the club are never closed".
"If, one day, he is in good enough condition to play, and proves he is well, then we could be interested, as all good footballers interest us,'' she told Brazilian newspaper Terra.
"The doors of the club are never closed. The rescinded contract was only signed in August, and I remember that the fans wanted this deal to happen too.
"At the moment, he's not the player for us, but he was the star of the team when we won the championship, and he knows how we operate here.
"We have given him our love, affection and commitment, but he has not repaid us. We are always ready to help him, but he knows that he cannot play in his current condition."
Information from the Press Association was used in this report.