Ashley Cole has been ruled out of England's opening World Cup qualifier against Moldova due to an ankle injury.
Cole has been struggling since Chelsea's UEFA Super Cup defeat against Atletico Madrid on Friday and will not travel to Chisinau for this Friday's Group H clash.
The 31-year-old will be re-assessed on Sunday to determine whether he would be fit for next Tuesday's home game against Ukraine.
The injury has ended Cole's hopes of becoming the first full back to win 100 caps during this month's doubleheader.
He is currently on 98 and will have to wait until at least next month to reach the century mark.
It was unclear on Monday whether his ankle injury was related to the long-standing issue that has needed to be managed after matches for his club and country.
He will return to Chelsea for treatment this week before linking up again with his international teammates.
Striker Andy Carroll had already withdrawn from what had been a 24-man party after suffering a hamstring injury in his West Ham debut on Saturday.
Hodgson was already without Wayne Rooney, who suffered a gashed leg playing for Manchester United before the squad was named.
England trained at their London Colney base Monday afternoon, with 16 of its remaining 22 players involved in the outdoor session.
They included John Terry, whose availability had been in doubt because of a neck problem picked up playing for Chelsea almost two weeks ago.
Terry looked looked completely untroubled by his recent neck injury as he headed several balls during the session of more than an hour.