Uruguayan side Liverpool became the last team to qualify for the Copa Sudamericana round of 16 after beating Envigado of Colombia 1-0 in Montevideo to complete a 2-1 aggregate win.
A bicycle kick by Damian Diaz helped Ecuadorian side Barcelona make it into the Copa Sudamericana round of 16 with a 4-3 win over Chile's Cobreloa.
Ecuadorian champions Deportivo Quito made it into the Copa Sudamericana round of 16 with a 3-1 away win over Aurora in Bolivia.
Argentina's Colon Santa Fe advanced to the last 16 of the Copa Sudamericana by knocking out compatriots Racing Club.
Argentinian side Independiente reached the last 16 of the Copa Sudamericana after eliminating compatriots Boca Juniors on away goals.
Emelec of Ecuador clinched a valuable win in Paraguay by defeating Olimpia 1-0 in the first leg of the Copa Sudamericana's second round.
Brazilian giants Sao Paulo reached the Copa Sudamericana round of 16 after a 2-0 home win over domestic rivals Bahia.
Two goals from Uruguayan midfielder Diego Ferreira helped Argentinian side Tigre to record a valuable 2-1 away-win over compatriots Argentinos Juniors in the first leg of their Copa Sudamericana second round tie.
Uruguayan giants Nacional made it into the Copa Sudamericana second round as they hammered Chile's Iquique 4-0 in the second leg of the first round.
Chilean giants Universidad Catolica outclassed Bolivian rivals Blooming 3-0 on Thursday night to secure a 4-1 aggregate win and advance to the second stage of the Copa Sudamericana.