Paraguayan side Olimpia won Copa Libertadores Group Seven in style with a 4-1 win over Newell's Old Boys - who also advanced to the last 16 despite the hammering.
Reigning champions Corinthians had no trouble securing top spot in Copa Libertadores Group Five with a 3-0 win over Bolivia's San Jose.
Colombian side Santa Fe progressed to the Copa Libertadores last 16 with a 2-1 away win over compatriots Tolima.
Argentine club Arsenal have paid a $20,000 fine to ensure that seven of their players avoid charges after a brawl involving police officers following their Copa Libertadores match on Wednesday.
Argentine club Arsenal have found themselves in trouble with the law after a brawl involving police officers following their Copa Libertadores match on Wednesday.
Brazilian outfit Atletico Mineiro maintained its perfect start to the Copa Libertadores after thumping Arsenal 5-2 at the Estadio Raimundo Sampaio.
Ronaldinho, Neymar and Alexandre Pato have been named in the Brazil squad for Saturday's friendly against Bolivia, with Luiz Felipe Scolari combining a mixture of youth and experience ahead of the exhibition match.
Argentinian side Velez Sarsfield booked a berth in the Copa Libertadores round of 16 with a 3-1 away win over Chile's Deportes Iquique.
Copa Libertadores runners-up Boca Juniors clinched a vital 1-0 win over Uruguayans Nacional to maintain their chances alive in the Group One.
Brazil club Atletico Mineiro became the first team to qualify for the Copa Libertadores last-16 after beating Bolivian side The Strongest 2-1.