Colombian side Santa Fe secured their qualification to the Copa Libertadores semi-finals after beating Peru's Real Garcilaso 2-0 to claim a 5-1 aggregate win.
Argentinean giants Boca Juniors and Newell's Old Boys played out a goalless draw in the first leg of their Copa Libertadores quarter-final.
Colombian side Santa Fe took a big step towards the semi-finals of the Copa Libertadores by beating tournament debutants Real Garcilaso 3-1 in Peru in the first leg of their last-eight clash.
Defending champions Corinthians were ousted from the Copa Libertadores on Wednesday night, with a 1-1 draw in Brazil seeing six-time winners Boca Juniors advance to the quarter-finals 2-1 on aggregate.
Mexican side Club Tijuana have set up a Copa Libertadores quater-final showdown with Ronaldinho's Atletico Mineiro after knocking out Brazil powerhouse Palmeiras.
Peruvian side Real Garcilaso caused a major Copa Libertadores shock as they eliminated Nacional on penalties at the last-16 stage.
Atletico Mineiro came from behind to beat the 10 men of Sao Paulo 2-1 away from home in the first leg of their all-Brazilian Copa Libertadores Round of 16 tie.
Boca Juniors have banished the demons of their domestic form to claim a slender 1-0 victory over Brazilian side Corinthians in the Copa Libertadores.
Argentinian side Tigre edged out Paraguayan giants Olimpia 2-1 to boost their hopes of reaching the quarter-finals of the Copa Libertadores.
Former Real Madrid manager Vanderlei Luxemburgo has been suspended for six matches after his involvement in a brawl during Gremio's Copa Libertadores match with Huachipato.