Chris Wondolowski scored twice and Innocent Emeghara added goal in the San Jose Earthquakes' 3-2 victory over the Seattle Sounders.
San Jose played nearly the entire second half a man down after Victor Bernardez was sent off in the 52nd minute for a bad tackle attempt.
Clint Dempsey opened the scoring with a record-breaking goal for the Sounders at the 18-second mark. Dempsey headed in a rebound off a miss by Tyrone Mears to score the club's earliest goal in a game. The previous record was held by Eddie Johnson, who scored a second-minute goal in 2011 against Colorado.
Wondolowski tied it at 1-1 in the 13th minute. Wondolowski settled a cross from Marvell Wynne with his chest and easily beat goalkeeper Stefan Frei.
Wondolowski then made it 2-1 in 48th minute after Brad Evans was unable to clear a ball in the box back to Frei. The loose ball was easily taken by Wondolowski, who finished cooly.
Wondolowski has scored nine against the Sounders, the most by any active MLS player against the club.
Innocent Emeghara made it 3-1 in the 70th minute before Obamefi Martins cut the deficit to 3-2 in the 84th.
In Columbus, Justin Meram and Kei Kamara scored and the Columbus Crew took advantage of a controvsial red card to beat Toronto FC 2-0 on Saturday night.
At the end of a scoreless first half, Toronto's Justin Morrow was sent off for a tackle on Ethan Finley just outside the box.
In the 57th minute, Finley's perfect cross from the right flank found Meram, who calmly headed it past a diving Joe Bendik for a 1-0 lead.
Kamara made it 2-0 four minutes later with a close range half-volley of a feed from the left by Waylon Francis.
Columbus had 21 total shots with seven on target. Steve Clark made two saves to register his first shutout of the season, the ninth of his MLS career.
Blas Perez scored twice and FC Dallas topped Sporting Kansas City 3-1.
FC Dallas broke out quickly, with Perez finding the back of the net in the 17th minute. Tesho Akindele left a touch pass from the top of the box for Perez, who made no mistake on the finish.
Sporting KC drew even just before halftime, as Roger Espinoza completed a long run with a stutter step just inside the box, and then beat Chris Seitz near post with a left-footed blast.
Perez made it 2-1 in the 52nd minute with his third goal of the season. Seemingly offside, Perez had time to chest-trap a pass from Michel, settle the ball, and fire past Luis Marin from close range.
FC Dallas got insurance in the 73rd minute as Fabian Castillo beat Marin to the dot for a ball from Ryan Hollinghead and tapped it home.
Octavio Rivero scored in the 86th minute and the Vancouver Whitecaps beat the Chicago Fire 1-0 on Saturday for the their first away victory in five attempts in the Windy City.
A failed clearance fell to the feet of Steven Beitashour on the edge the 6-yard box. He fed it to the penalty spot where an open Rivero slotted it inside the left corner past a diving Jon Busch.
Rivero, who had Vancouver's only goal in its home opening loss to Toronto FC, ran past the defense in the 74th minute but his shot went wide of the near post.
Meanwhile in Utah, Alvaro Saborio scored a penalty in the 86th minute as Real Salt Lake salvaged a 3-3 draw against the Philadelphia Union.
Luke Mulholland was tackled late by Fernando Aristeguieta in the box to set up the penalty kick.
Real Salt Lake scored first with a freekick by Javier Morales after Saborio was knocked out of the air on a header.
Philly evened it in the 34th minute. A cross deflected off an RSL defender, forcing Nick Rimando into a scrambling save. Aristeguieta got behind the defense and headed the rebound into an open net. Four minutes later, Aristeguieta took advantage of an out of position Salt Lake defence on a throw-in and he went far post.
Salt Lake tied it in the 55th minute as a cross bounced off several RSL players and Jamison Olave, falling down, headed it home. Moments later, Olave deflected a cross past his own goalie to put the Union back up 3-2.