On a day of major upsets, Southampton joined other top Premier League clubs on their way out of the FA Cup, much to the chagrin of Saints boss Ronald Koeman.
Southampton joined Chelsea, Manchester City and Tottenham in bowing out of the competition on Saturday, and Koeman called the Saints' 3-2 defeat at Crystal Palace a "pity."
"'Everybody will say the same -- it's a pity because the big ones are out of the FA Cup,'' the Dutchman said. ''You know it's difficult to beat every team, not about the level because everybody is fighting to win games in the FA Cup."
All five goals came in the first half, with Graziano Pelle opening the scoring after nine minutes -- only for Marouane Chamakh to draw parity moments later.
Scott Dann's own goal put Saints back in the driving seat, only for Yaya Sanogo to score his first goal for Palace before Chamakh rounded the goalkeeper to slot home what proved a 39th-minute winner.
Southampton will now concentrate on the Premier League, where they are serious contenders for a Champions League spot.
"It was a difficult one -- we knew it before," Koeman said. "Crystal Palace are doing well with a new manager and they punished the mistakes we did in the first 45 minutes. Now total focus [goes] to the Premier League for next week.''
To make matters worse for Saints, their list of absentees grew further after substitute Shane Long had to be taken off following a collision with Palace defender Joel Ward.
''I spoke to the doctor and he thought he will have fractured one or two ribs and that's very painful,'' Koeman said of the striker, who was taken to hospital.
''It's a pity because we don't have that number of players to go with all the injuries that we have. 'I don't know [how long he is out]. Normally three, four, five weeks.''