Chelsea kept up the pace at the top of the Premier League with a comprehensive win at home to Spurs, but Man City ensured the gap would stay at six points with a crushing win at Sunderland.
Arsenal needed a late goal to take the points at home to Southampton, and Hull City ended their losing run by claiming a draw at Everton.
Didier Drogba set up Eden Hazard's opener before scoring himself as Chelsea swept aside Tottenham with a 3-0 victory to extend their unbeaten start to the season.
Although Tottenham threatened early on, with Harry Kane heading against the crossbar, Chelsea took control after a Drogba-Hazard one-two created the Belgium midfielder's goal in the 19th minute.
Tottenham gifted Chelsea another goal inside three minutes, with goalkeeper Hugo Lloris' weak clearance allowing Hazard and Oscar to combine to set up Drogba's fifth goal of the season.
Easily coping without suspended top scorer Diego Costa, Chelsea exposed the feeble Tottenham defence again in the 73rd minute when substitute striker Loic Remy sidefooted in the third goal after brushing off Jan Vertonghen.
Manchester City ended a six-year wait for a Premier League win at Sunderland with an impressive 4-1 victory.
The visitors, who had lost their last four games at the Stadium of Light, fell behind in the 19th minute when Pablo Zabaleta's attempted clearance deflected off Connor Wickham and into the net.
But Sergio Aguero levelled two minutes later, rolling the ball through defender Sebastian Coates' legs before unleashing a vicious shot past goalkeeper Costel Pantilimon.
City went ahead in the 39th minute when Aguero found Stevan Jovetic, who netted from inside the area. Zabaleta added a third in the 55th minute when he lifted the ball over Pantilimon, before Aguero hit the fourth in the 71st.
Alexis Sanchez rescued Arsenal again by scoring in the 89th minute to secure a 1-0 win over Southampton.
Sanchez slotted into an empty net after Aaron Ramsey squared the ball across the goal, finally breaking down a Southampton side who had been kept in the game by a series of good saves by Fraser Forster.
It was the Chilean's ninth league goal of the season and kept Arsenal in sixth place, three points behind third-place Southampton.
Arsenal had struggled to create chances until Olivier Giroud came on midway through the second half, and Forster made two great one-handed saves to deny the France striker and Danny Welbeck as the hosts pushed for a winner.
Hull City's run of defeats came to an end as an equaliser from substitute Sone Aluko secured them a 1-1 draw at Everton.
The Toffees appeared very much in control at half-time, going in a goal up thanks to Romelu Lukaku's 34th-minute strike from a Kevin Mirallas cut-back.
But Hull battled back after the break and were level in the 59th minute when Aluko, only just introduced to the action, got past Sylvain Distin and put a nice finish past Tim Howard at his near post.
The Tigers' ex-Everton frontman Nikica Jelavic headed just wide moments later, and the visitors then hung on doggedly for a draw that takes them out of the relegation zone, which they had slipped into on Tuesday night.
Steve Bruce's men are only up a place from 18th to 17th and are clear of the drop zone on goal difference alone, but they will surely take a considerable boost from getting this point on the board after losing their previous four games.