Barcelona remain at the top of the La Liga table following a comfortable yet unremarkable 2-0 win at Rayo Vallecano, who had two men sent off in the second half.
The Madrid side made a promising start to the game but Lionel Messi got the visitors off the mark after 34 minutes and a moment later Neymar doubled the advantage to kill off Rayo's hopes.
The hosts were reduced to 10 men on the hour mark when Jorge Morcillo received a second booking, and Rayo forward Javier Aquino suffered the same fate in injury time, but they conceded no further goals.
Barca goalkeeper Claudio Bravo also made club history by keeping a record seventh consecutive clean sheet.
Atletico Madrid suffered their first league defeat of the season as they were overpowered by a rampant Valencia side, who scored three goals in a chaotic opening 13 minutes to win 3-1 at the Mestalla.
An own goal from Miranda put the hosts in front with just six minutes played and a well-taken goal by Andre Gomes doubled their lead a minute later, while Nicolas Otamendi's header completed the early blitz.
Mario Mandzukic hit back for Atletico and threatened to spark a revival, but hopes of staging a comeback were stopped in their tracks when Guilherme Siqueira had a penalty before the break saved by Diego Alves. Substitute Alessio Cerci thought he had scored a consolation goal for Atleti in stoppage time, but the effort was chalked off for handball and he was subsequently sent off for a second yellow card.
Federico Piovaccari's last-gasp strike snatched a point for Eibar in a thrilling 3-3 draw with Levante.
Jose Luis Mendilibar's Levante side took the lead through Jose Luis Morales after just two minutes and doubled their advantage before half-time courtesy of Victor Camarasa.
The visitors seamed to be cruising but an own goal by Pedro Lopez at the start of the second half revitalised the hosts and they then drew level through Saul Berjon's wonder goal.
Victor Casadesus looked to have sealed the points for Levante with a superb strike of his own in the 79th minute, but substitute Piovaccari had the last word, with the Italian striking into the back of the net in the third minute of added time.
Ten-man Malaga came from behind to steal a 2-1 victory against Andalusian rivals Granada.
Malaga were stunned when Youssef El-Arabi gave Granada the lead in the first minute, but the hosts hit back when Roque Santa Cruz levelled just after the hour mark.
Marcos Angeleri saw red in the 73rd minute but, despite being a man down, Malaga clinched all three points when Vitorino Antunes converted a penalty 10 minutes from time after Manuel Iturra was adjudged to have handled in the area.
Hero Jonathas turned villain as 10-man Elche held on to claim their first point in four matches from a 2-2 draw against Almeria at the Juegos Mediterraneos.
Almeria took the lead through Victor Rodriguez before Jose Antonio Verza made things level at the break.
Jonathas put the visitors back in front 10 minutes after the interval before he saw red for a second bookable offence and Tomer Hemed rescued a point for Francisco Rodriguez's men late on.