Shrewsbury Town, the lowest ranked team left in the Capital One Cup, have been drawn against Premier League side Chelsea in the fourth round.
League Two Shrews, who knocked out Championship side Norwich in the last round, host a Blues side who were 2-1 winners over Bolton on Wednesday night.
Holders Manchester City, who thumped Sheffield Wednesday 7-0 at the Etihad, will play Newcastle in an all Premier League affair.
Liverpool, who progressed after a marathon 14-13 penalty shootout win over Middlesbrough on Tuesday night, take on Swansea in an another contest between two top flight clubs.
Stoke host in-form Southampton at the Britannia while Tottenham are at home to Brighton, who were 3-0 winners at Burton.
The other fourth round ties see Sheffield United travel to MK Dons and Fulham play Derby.