Daniel Sturridge has been ruled out of England's opening 2016 European Championship qualifier after picking up a thigh injury during a team training session on Friday morning.
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Sturridge, 25, underwent a scan on Friday afternoon to determine the extent of the injury, with the Euro 2016 Group E tie at Switzerland only three days away.
And he has now been told he won't play a part in the Euro 2016 qualifier.
An FA Spokesman said: "Daniel Sturridge picked up an injury on his thigh in training. He has had a scan and will now return to Liverpool FC for treatment. He will play no part in the forthcoming Switzerland match."
Heartbroken soul right now believe me. Hopefully be back soon fighting fit for LFC. Nothing worse than being injured. My heads gone... ��
- Daniel Sturridge (@D_Sturridge) September 5, 2014
England will travel to Switzerland on Sunday morning with just 19 players, two of whom are goalkeepers. If England manage to avoid any more injuries, six outfield players will be on the bench at St Jakob-Park.
Danny Welbeck looks likely to replace Sturridge in the starting XI, as the new Arsenal signing was one of the few players to come out of the win over Norway with his reputation enhanced.
Indeed, Jack Wilshere backed his new Arsenal team-mate Welbeck to have a successful season for club and country.
''He is a great addition for Arsenal and hopefully he will keep performing for England as well,'' he said. ''He has got great enthusiasm, he wants to run, he will track back, and he has got great quality.
''A lot of people don't give him credit for his technical ability, but he is great on the ball. I am sure there were a few clubs wanting him and there are not many players his age who move from one big club to another big club so that shows his quality.''
Just 40,181 people turned up to watch the victory against Norway but Wilshere thinks England can start to win the fans back by beating the Swiss in Basle on Monday night.
''Going over to Switzerland is a tough game but we know if we put in the performance and get the result the fans are going to come back on our side,'' said Wilshere, who thinks the negative reaction to England's winless World Cup campaign has been over the top.
''If people analysed it a bit more they would have been a bit kinder, there were just a few individual errors and a few lapses in concentration - but at that level that is what you are going to get.
''When you are playing against (Mario) Balotelli and (Luis) Suarez that is what you are going to get, they are going to punish you and they did. But if you look at the games, we had more positives than people give us credit for.''
Wilshere only started one game at the World Cup -- against Costa Rica in Belo Horizonte -- but with Steven Gerrard and Frank Lampard now retired, he is one of the first names on the teamsheet.
Injury has hindered the 21-cap midfielder, but he says he is now almost back to peak fitness.
He said: ''It is a big season for me. I have never hidden away from that. 'I have had a good pre-season for the first time in a few years, I have trained every session, played in all but one of the games. I feel good, I am getting stronger and stronger, I am getting near to where I want to be.''
Wilshere knows he and Jordan Henderson, who wore the No. 4 shirt vacated by Gerrard on Wednesday, have big shoes to fill.
He added: ''Obviously it's disappointing when Steven and Frank retired, they were massive players for England, over the last 10 years they were great ambassadors and that is the level we have got to get to."
Information from the Press Association was used in this report.