Chelsea and Real Madrid will play their preseason International Champions Cup match on Saturday, July 30, at Michigan Stadium in Ann Arbor.
"The Big House," home to the University of Michigan, has a listed capacity of 107,601 and is the largest stadium in the United States.
In 2014, Manchester United beat Real Madrid 3-1 in front of 109,318 fans at Michigan Stadium, a record attendance for a soccer game in the U.S.
"We look forward to passing that number in July of this year," said Michigan athletic director Warde Manuel. "It's an exciting opportunity for our community and soccer fans everywhere."
#TBT: We fit 109,318 people into the Big House for @realmadrid in 2014.
Can. We. Do. Better? #ICC2016 pic.twitter.com/6sqbFJLmUZ
- Int Champions Cup (@IntChampionsCup) March 24, 2016
Michigan will lay down thick-cut sod on top of its FieldTurf for the match as they did two years ago.
"We know that it will be a preseason game. It will be a big test for us and it will be an opportunity to prepare as much as we can before an important and long season," said Chelsea ambassador Paulo Ferreira.
"Especially to play against such a big side will be fantastic. We know it's a friendly game and tournament, but we'll want to give our best."
Most of the International Champions Cup games were announced earlier this week, including Madrid's clash with Paris Saint-Germain at Ohio Stadium.
The game in Michigan will be the second of Chelsea's three-game tour in the competition, following a match against Liverpool at the Rose Bowl in Southern California on July 27.
The third game, against AC Milan on Aug. 3, will open the Minnesota Vikings' brand new US Bank Stadium in Minneapolis.
Madrid also finish their own three-match tour on Aug. 3 at an NFL stadium, MetLife Stadium in East Rutherford, New Jersey.
ESPN.com blogger Dan Murphy contributed to this report.