Germany coach Joachim Low is expected to drop Mario Gomez, Thomas Muller and Lukas Podolski for the Euro 2012 quarter-final clash with Greece.
Reports in the German media from newspaper Bild and Sky Sport claim Miroslav Klose, Andre Schurrle, and Marco Reus will all start in what is being billed as 'The Debt derby' given the ongoing Eurozone crisis affecting both countries.
Germany won all three of their group games, Gomez scoring three times as Netherlands, Portugal and Denmark were beaten.
But Low could decide to freshen things up against the most unfancied team who have made it to the last eight of the tournament.
He had said in the build-up to the game: "I am not afraid to make different choices and change the team."
Greece, the 2004 champions, are without influential skipper Giorgos Karagounis through suspension, but will be boosted by the news that three of Germany's most influential players could be missing.
Low also made controversial changes for his side's Euro 2008 quarter-final victory over Portugal, bringing in Thomas Hitzlsperger and Simon Rolfes.
German prime minister Angela Merkel is expected to be present at the match in Gdansk and she is likely to receive a hostile welcome from the Greek fans inside the stadium.
The match is being played against the backdrop of financial difficulties on Europe's markets with Germany insisting on sweeping austerity measures in Greece after offering billions worth of aid.