Tom Craddock grabbed his fifth goal in three games to help Oxford to just their second League Two away win of the season as they beat fellow strugglers Wycombe 3-1.
The 26-year-old striker, who scored four last weekend at Accrington, set up the first for James Constable before firing past Nikki Bull at the start of the second-half.
Joel Grant instantly pulled one back from the penalty spot but Johnny Mullins headed in a third for the U's for their first league win on the road since August.
Oxford went ahead after just four minutes when Constable combined with Craddock before unleashing a fierce half-volley into the bottom corner of the net for his first league goal of the campaign.
Constable then saw a goal ruled out for offside before Craddock, who drew a blank in midweek, smashed a long ball past Bull less than a minute into the second half.
The Wycombe response was instant with Constable fouling player-manager Gareth Ainsworth in the box and Grant tucking the penalty home.
Mullins snuffed out the revival though when he headed home Sean Rigg's cross on 62 minutes.