Bryan Ruiz and Marc Janko both scored twice as FC Twente moved level on points with Eredivisie leaders PSV Eindhoven with victory at NEC Nijmegen.
Ruiz cancelled out Bas Sibum's opener and Janko put the visitors in front for the first time in the 40th minute.
A Ruiz penalty gave them a two-goal cushion going into half-time, and that was re-established by Janko 11 minutes from time after Bjorn Vleminckx had pulled one back.
Champions Twente went into the game on the back of consecutive defeats, and it looked like their hopes of defending their title might take another hit when they went behind after nine minutes.
John Goossens' free-kick from the right was flicked on by Lasse Schone for Sibum to rifle the ball home low from six yards.
But Ruiz, whose 24 league goals last term were key in Twente winning the title, levelled in the 18th minute as he found the bottom corner after Ramon Zomer's clearing header fell to him on the edge of the area.
And Janko, the summer signing from Salzburg, put the visitors in front after a combination of excellent work from Nacer Chadli and kamikaze defending.
Lasse Schone tried to shepherd the ball out of play, but Chadli got round him to get a cross in to the six-yard box. Goalkeeper Jasper Cillessen had already left his goal to get in position to take the goal kick he assumed was coming, leaving Janko, in the middle, the simplest of tasks to finish into an empty net.
Ruiz made it three from the penalty spot a minute before the break, calmly sending Cillessen the wrong way after Luuk de Jong had been fouled by Rens Van Eijden.
Twente threatened to pull further clear in the second half, De Jong turning and shooting low only for Cillessen to make the save and Chadli curling a free-kick against the bar before it was scrambled clear by the defence.
Ruiz was denied a hat-trick by the frame of the goal in the 70th minute as low shot following a fine run into the area came back off a post.
Instead NEC boosted their hopes of a comeback as Schone went some way to making up for his earlier error by picking out Vleminckx with a through-ball from the right and the striker crashed home his side's second.
But those hopes were dashed 11 minutes from time as Ruiz turned provider, crossing for Janko to head home a fourth.