Exeter look unlikely to gamble on John O'Flynn's injury for the Johnstone's Paint Trophy clash with Wycombe.
The Irishman limped off 22 minutes into the 2-1 win over York on Saturday with a hamstring tweak and manager Paul Tisdale is unlikely to risk the former Barnet forward.
And Tisdale could freshen his side up with the likes of Jamie Reid, Jake Gosling and Alan Gow all starting against the Chairboys.
The Grecians have lowered their ticket prices for the 7:15pm kick off as they look to extend their 100 per cent home record at St James Park this season.
Wycombe will be without Josh Scowen for the trip to face Tisdale's men on the south coast.
The midfielder rolled his ankle in Saturday's 2-1 win over Southend and had to be substituted just 19 minutes into the match.
His place in the starting line-up could be taken by the Chairboys' captain Stuart Lewis who is back from suspension.
Steven Craig netted his first goal in English football on Saturday and manager Gareth Ainsworth could reward the match-winner with a place in his starting line-up at St James Park.