Scunthorpe skipper Michael Collins and defender Christian Ribeiro could both return to the squad to face Exeter.
Midfielder Collins has not featured since late August due to a knee injury and Ribeiro has been sidelined since early September with a groin problem.
Boss Brian Laws, who confirmed this week that both players were close to a return to action, will be without full-back Eddie Nolan (hamstring) and winger Andy Welsh (knee).
Laws could name the same side that started in the win over Cheltenham in their last game as the Iron, who have lost only once this season, look to extend their unbeaten run to eight matches.
Exeter look set to be without experienced duo Matt Oakley and Danny Butterfield.
The Grecians will travel over 900 miles in four days with the Tuesday night trip to Oxford on the horizon and Oakley (ankle) and Butterfield (calf) are not expected to feature in either match.
Butterfield's absence could see Pat Baldwin return to right-back with Scot Bennett dropping back into the centre of defence or Jordan Moore-Taylor may be asked to play there again having done so as a first-half substitute against Hartlepool last Saturday.
Sam Parkin is set to return to action having been missing for almost a month with a hamstring injury while fellow forward John O'Flynn came through his return against Pools unscathed.