Tranmere's lengthy injury list will not subside in time for any of their current absentees to feature against table-topping Leyton Orient.
Ronnie Moore has over half-a-dozen Rovers players missing as he tries to plot a way to end the only remaining unbeaten record in Sky Bet League One.
Skipper James Wallace (knee), fellow midfielders Jason Koumas (groin), Andy Robinson (knee) and Joe Thompson (illness), goalkeepers Jason Mooney (knee) and Sam Ramsbottom (ankle), defender Evan Horwood (groin) and striker Jean-Louis Akpa Akpro (abscess) all remain sidelined.
Moore is hopeful Koumas and Thompson will be back next week while Wallace could miss the next month and Robinson has had an operation on his knee which will likely keep him out for up to six weeks.
Leyton Orient will check on Elliot Omozusi.
The full-back suffered a groin injury as the O's stretched their unbeaten run to 13 matches with a 2-1 win over MK Dons last Saturday.
Striker Kevin Lisbie had barely trained all week prior to that match due to a dead leg, but he recovered sufficiently to score the winner and is expected to start again.
There could be a change on the bench as youngster Johnny Gorman is back from international duty with Northern Ireland Under-21s.