Yeovil will hand goalkeeper Wayne Hennessey his first competitive appearance since April 2012 when Derby come to Huish Park.
The Wales international has joined on loan from Wolves after injuries to Marek Stech and then Sam Johnstone who played just one game having been borrowed from Manchester United.
And Hennessey will be thrown straight into the starting line-up against the Rams and become the fourth goalkeeper to play for Gary Johnson's men in just four league games.
Captain Jamie McAllister has returned to training and just needs another week or so before he is considered while Stech is sidelined for three months with a broken finger.
Derby will travel with an unchanged squad.
Central defenders Mark O'Brien and Shaun Barker remain the only absentees as they continue their rehabilitation following knee injuries.
The Rams suffered their first defeat of the season last Saturday as Leicester won 1-0 at Pride Park. Nigel Clough felt his side were unfortunate to lose but the manager could still freshen up his starting XI against the Glovers.
Right-back Adam Smith, on loan from Tottenham, is awaiting his first league start while midfielders Michael Jacobs, John Eustace and Ben Davies and forwards Jamie Ward and Conor Sammon were all on the bench against the Foxes and could come into Clough's thinking.