Luton boss Paul Buckle will be forced to make changes ahead of their FA Cup third-round meeting with Wolves.
Defender Simon Ainge and winger Scott Neilson, who both played in Tuesday's 3-1 Blue Square Bet Premier defeat at Woking, are cup-tied.
Jonathan Smith is likely to fill in for Neilson having scored the late consolation as a substitute in that game.
JJ O'Donnell provides further options in the middle while Lathaniel Rowe-Turner is expected to deputise for Ainge.
Buckle could not hide his disappointment in midweek as they suffered a second league defeat in three, but admitted the visit of the npower Championship side gives his side the chance to put on a performance.
``Everyone's going to be up for it. It's normal FA Cup, that's what happens,'' he told Dunstable Today. ``It's these games (Woking) where everyone has got to be tougher. It's easy to say let's get up for a game against Wolves in the cup.
``But obviously we'll give it our all and want to win the game like any other.''
Bakary Sako is the latest Wolves player to be struck down by injury.
Wanderers' influential winger was forced off with a hamstring complaint after an hour of the 3-1 New Year's Day defeat at Crystal Palace - a third successive reverse over the festive period - and is now a huge doubt to face the Hatters.
Fellow midfielders Tongo Doumbia (hamstring) and Bjorn Sigurdarson (thigh) missed the game altogether, with the latter boasting a slight chance of being fit for the tricky cup tie.
Winger Slawomir Peszko is close to making his return after three months out with a knee injury and whether he is included in under-pressure boss Stale Solbakken's matchday squad remains to be seen.
Razak Boukari, Dave Edwards, Steven Mouyokolo, Wayne Hennessey, Stephen Hunt and George Elokobi remain absent.