Queen's Park are hoping midfield dynamo David Anderson will be fit to take his place in the starting line-up when Stranraer visit Hampden, with a home tie against Dundee United up for grabs.
Anderson injured a knee in the 1-1 draw between the sides last Saturday and only returned to training on Thursday, with head coach Gardner Speirs rating him as doubtful.
Winger Sean Burns has been ruled out through work commitments but Speirs hopes that striker Jamie Longworth, who has been ill this week, recovers in time.
Speirs said: ``The first game was a cracking cup tie and I'm hoping this one is the same but we win. Dundee United is a big prize but Stranraer will want it just as much as us.''
Stranraer defender David MacGregor is in line for his first start of the season.
Former Morton man MacGregor made a substitute appearance in the 1-1 draw between the teams last Saturday following a knee injury and built on that in a midweek bounce game.
Ryan Borris is the only doubt with a thigh strain.
Stair Park manager Steve Aitken said: ``We have missed David's experience all season and it looks like we will be able to call on him for this one.
``With the possibility of a game against Dundee United in the next round it would be great to have as strong a team as possible fighting for it.''