Queen's Park will be without defender Jamie Brough against Clyde following his dismissal in Saturday's last-gasp 1-0 defeat to Rangers.
Paul McGinn hopes to shake off a virus that has troubled him for a few days to feature with head coach Gardner Speirs likely to freshen things up after the exertions of the weekend.
Speirs said: ``We received plenty of praise for the Rangers game but no points and it is time to move on. A number of the players were dead on their feet after the game and I will decide my team on Wednesday morning once a few bumps and bruises have healed but I will make some changes.
``Clyde are coming here after a good win and will be looking to get the three points.''
Clyde manager Jim Duffy will make a late check on Gavin Brown, who missed out on Saturday's win due to a hamstring problem, at Hampden as well as Iain Gray who was suffering from tonsillitis.
Broadwood boss Duffy is looking for his side to show the same level of application as they did in defeating Berwick 2-1 on Saturday as they look to stop a run of eight straight defeats against Queen's Park.
``We were a goal down but the players worked incredibly hard to get level and then win the game,'' Duffy said. ``We will need that approach again as whilst Queen's Park's performance against Rangers surprised many it did not surprise me.
``They usually put on that level of performance against us as the record shows.``