Graham Westley takes charge of his first game back in charge of Stevenage against Hartlepool.
Westley has returned to Boro, who he guided to back-to-back promotions before leaving for Preston, to replace Gary Smith who was sacked last week.
He will be without Miguel Comminges, who is suspended after his red card in Friday's 1-1 draw against Crawley.
With Lee Hills a doubt with a hamstring problem, David Gray is set to fill in at left-back.
Midfielder Gavin Mahon is struggling with a knock but new signings Alex Smith and Roarie Deacon could be added to the squad.
Defender Smith joined on loan from Fulham on Thursday and forward Deacon was a free agent after leaving Sunderland, but neither signed in time to face Crawley.
Hartlepool will be without suspended midfielder Simon Walton and three other players could miss out through injury.
Walton was shown a straight red card in Friday's home defeat to MK Dons for his challenge on Patrick Bamford and will start a three-game ban.
Manager John Hughes could also be without fellow midfielder Ritchie Humphreys again after he missed out against the Dons due to a calf strain.
Defender Evan Horwood and midfielder Antony Sweeney are also doubtful after they both sustained hamstring strains during Friday's setback.
Teenager Jack Baldwin made a surprise return to action on Friday following knee ligament damage and played the full 90 minutes, so he too could be struggling to last a second full game in the space of four days.
Charlie Wyke, on loan from Middlesbrough, overcame a heel problem in time to start against the Dons and although fellow striker James Poole missed out due to a knock, he could return to contention to boost Hughes' attacking options following Thursday's departure of Steve Howard to Sheffield Wednesday on loan.