Leeds' new loan signings Alan Tate and Jerome Thomas will go straight into the starting line-up against manager Neil Warnock's former club Crystal Palace.
Swansea defender Tate arrived on loan until January this week in time to make his debut for the club in the absence of Jason Pearce, who sits out the second of his three-game ban following his recent dismissal against Watford. Thomas, who arrives from West Brom, will also stay until the New Year.
Striker Luke Varney is also missing as he starts a three-match suspension for his straight red card in last Sunday's defeat at Millwall.
Midfielder Michael Brown will return to contention after sitting out a one-match ban last week and teenage forward Dominic Poleon will return to the squad after being recalled from his loan spell at Bury.
Warnock has still to decide whether to start with last season's leading goalscorer Ross McCormack, who stepped off the substitutes' bench last week in his first appearance since mid-September due to an ankle injury.
Midfielder Rudy Austin is sidelined with a cracked ankle bone, while utility player Danny Pugh, winger Aidy White, defender Paddy Kisnorbo and midfielder David Norris are all pushing for recalls as Leeds chase a first win in their last eight league matches.
Ian Holloway has only one injury doubt for Palace.
Defender Darcy Blake has been suffering with an illness and is unlikely to make the matchday squad. Should the 23-year-old miss out he is likely to be replaced by Dean Moxey.
Skipper Paddy McCarthy and midfielder Jonathan Williams are both ruled out through injury.
A 3-0 win against Derby last weekend ensured Holloway is yet to taste defeat as Eagles boss, with the Selhurst Park outfit currently two points clear at the top of the npower Championship.
Palace are unbeaten since August and have not lost since the 4-1 Capital One Cup defeat to Preston.