Leeds will face Hull at Elland Road without striker Ross McCormack, who will be sidelined for several weeks after twisting his ankle in the weekend defeat at Cardiff.
McCormack will undergo a scan once the swelling has gone down to determine the full extent of the injury, but is expected to be out for several weeks, prompting manager Neil Warnock into the loan market.
Warnock has limited resources available to replace McCormack. Luke Varney stepped off the bench at the weekend and was later replaced by teenage rookie Dominic Poleon, who made his second substitutes' appearance for the club.
Varney is expected to start alongside Luciano Becchio against Hull, although veteran Andy Gray provides Warnock with an alternative option. Davide Somma is not ready to return to match action following his recovery from knee ligament damage.
Defender Adam Drury is doubtful after sustaining a muscle strain against Cardiff, while midfielders Paul Green (knee) and David Norris (thigh) remain sidelined, so new loan signing Michael Tonge is likely to continue as Leeds chase a second away league win of the season.
Hull midfielder Seyi Olofinjana will undergo a late fitness test.
The Nigerian started only his second league match of the season in Saturday's home win over Millwall and was replaced in the 58th minute by Corry Evans due to a hamstring injury.
Evans will return to the starting line-up if Olofinjana fails to make it.
Defender Alex Bruce was also forced out of the action at the weekend after taking a knock to the knee, but is expected to be fit to face his former club.
Midfielder Paul McKenna sits out the final game of his three-match ban, striker Matty Fryatt is still sidelined with an Achilles injury and midfield pair Tom Cairney and Jack Hobbs remain long-term absentees due to respective long-term knee injuries.
Defender Liam Rosenior, summer signing Nick Proschwitz and Aaron McLean are all hoping to feature after starting on the bench against Millwall.