The fixtures aren't getting any easier. While Tottenham may have never scored at St Mary's they look like another stern test for the flailing Saints defence, even with home advantage.
Andre Villas Boas took over from our friend Harry Redknapp at Spurs in the summer and has a couple of points to prove. Firstly to show all the doubters who wrote him off after his spell at Chelsea and secondly to show that Spurs made the right decision in removing Redknapp.
They currently lie fifth in the Premier League table and will certainly see the Saints as a place to pick up another three points. The north London club haven't lost on the road since the opening day of the season and despite some disappointing results at Maribor and Panathinaikos in the Europa League, they have beaten Manchester United at Old Trafford.
The really bad news is that there will be a St Mary's reunion for Gareth Bale. The star pupil of the Southampton Academy and arguably the best player in the Premier League returns from paternity leave and will be the main dangerman. Spurs will be without Scott Parker, Younes Kaboul, Saints target Michael Dawson and Benoit Assou-Ekotto.
Jermain Defoe will likely lead the line and is in rich goalscoring form having netted six times this season in all competitions.
Tactically it looks like the Saints will need to contain Bale, but also get a grip of the impressive Mousa Dembele in midfield.
Southampton have Danny Fox, Luke Shaw and Tadanari Lee back from injury, with many wondering who will get the nod at left back.
Clyne Fonte Yoshida Shaw
Puncheon Davis Ward-Prowse Lallana
Keep the faith.