The Derby d'Italia is the biggest non-city derby in Italy and this weekend's meeting promises to be a fascinating clash between two clubs seemingly heading in different directions.
Juventus are the two-time defending Serie A champions and are dark horses for the Champions League this season. Inter on the other hand are in a rebuilding mode under new coach Walter Mazzarri and a top six finish this year will be a marked improvement over last season's disappointing ninth place.
But it is not all doom and gloom for Inter fans heading into the Juventus game. While they have only played two games in the league this season, Mazzarri's impact is clear to see already.
- Juventus and Inter primed for derby
Last season under Andrea Stramaccioni, Inter had one of the worst defences in Serie A, conceding 57 goals. Only Siena and Pescara let in that many. Incidentally, both those teams were relegated.
One of Mazzarri's first tasks when he took over was to make Inter stronger defensively, and the early results are encouraging. In Inter's first three games this season (two league and one cup) they have scored nine goals while keeping three clean sheets.
It is not just the goals against that are pleasing Inter fans. In their first two league games, Inter have allowed only nine shots on goal per game (leading the league) while making 26 tackles (second best in the league).
Inter will need that defensive strength on Saturday as Juventus possess the biggest attacking threat that Inter have faced all season.
It is quite remarkable how the fortunes of Inter and Juventus have diverged since Inter's treble winning season of 2010. Under Jose Mourinho Inter were dominating domestically (five straight Scudetto's) and in Europe (Champions League winners) while Juventus finished seventh that season.
The following summer (2010/11) Mourinho headed to Real Madrid as Inter stood still and Juventus began rebuilding their squad, spending over €53 million on new players.
While Inter engaged in managerial musical chairs, five manager (Rafael Benitez, Leonardo, Gian Piero Gasperini, Claudio Ranieri and Andrea Stramaccioni) in two years, Juventus continued rebuilding, spending an additional €88.5 million on new players in 2011/12.
Those two summers of almost €140 million in transfers paved the way for Juventus's back-to-back trophy winning seasons.
Unfortunately for Inter fans, the constant turnover of managers has resulted in wasted transfer opportunities since 2010 and declining fortunes on the pitch as Inter have finished second, fifth and ninth in the last three seasons.
Finally this summer Inter appeared to have a plan in place for the transfer market, but Mauro Icardi, Ishak Belfodil and Saphir Taider are players for the future. Not for this season.
Which brings me to this weekend's game which is a match-up of the experience of Juventus versus the youth of Inter.
Both sides are expected to play a variation of a 3-5-2 formation on Saturday. Defensively Inter will probably line-up with Hugo Campagnaro, Andrea Ranocchia and Juan Jesus against Juve's Carlos Tevez and either Fabio Quagliarella or Fernandro Llorente. Campagnaro has made a brilliant start to his Inter career, and Inter will need him to continue his terrific form if they are to shut down the potent Juventus attack.
At the other end of the pitch I expect Mazzarri to play Rodrigo Palacio in the more attacking role with Ricky Alvarez just behind him in the No.10 role. Juventus are expected to line-up with a back three of Angelo Ogbonna, Leonardo Bonucci and Giorgio Chiellini.
Alvarez has been one of the early stars in Serie A this season and Inter will need another big game from him on Saturday. The challenge will be scoring goals. Palacio is a nice player but he is not a pure goal scorer like Diego Milito, who could be a substitute on Saturday, as he recovers from his serious knee injury.
This is a game that I expect to be decided in midfield. Mazzarri is expected to start a midfield five of Jonathan, Fredy Guarin, Esteban Cambiasso, Mateo Kovacic and Yuto Nagatomo while Conte is expected to counter with Stephan Lichtsteiner, Arturo Vidal, Andrea Pirlo, Paul Pogba and Kwadwo Asamoah.
The challenge for Mazzarri and Inter is who marks Pogba? The former Manchester United man is the key player linking attack and the midfield and I am not sure if Cambiasso has the legs to keep up with Pogba for 90 minutes.
This game is coming a little too early in the season for Inter. The new players have not had enough time to get to know each other, its a short week due to the international break, and Milito is not quite fit.
If the game was played in December it might have a different outcome, but it is not and I expect Juventus's class up front to be the difference.